Endocrine Abstracts

Hashimoto’s thyroiditis (HT) is the most common inflammatory condition of the thyroid gland. In addition to the classic variant of HT, several other subtypes have been identified, such as the fibrous variant (HTFV).Case history: A 38 years old man noticed a rapidly enlarging lump in his neck month ago. This resulted in discomfort with choking sensation and mild dysphagia. He mentioned weight loss, tiredness and night sweats. He was a smoker and dran...

Hashimoto’s thyroiditis (HT) is the most common inflammatory condition of the thyroid gland. In addition to the classic variant of HT, several other subtypes have been identified, such as the fibrous variant (HTFV).Case history: A 38 years old man noticed a rapidly enlarging lump in his neck month ago. This resulted in discomfort with choking sensation and mild dysphagia. He mentioned weight loss, tiredness and night sweats. He was a smoker and dran...

Women affected by Cushing’s disease (CD) are often infertile due to abnormal follicular development or anovulation. In these patients, first line treatment is pituitary surgery, which is effective in more than 83% of cases with microadenomas, but only in about 35% of those with macroadenomas. When surgery do not normalize circulating ACTH and cortisol concentrations, such drugs, e.g. ketoconazole or metirapone, and radiotherapy are used as adjuvant treatment. Concerning r...

Testosterone has a dose-dependent stimulatory effect on erythropoiesis but the mechanism is poorly understood. Although both erythroblasts and megakaryocytes express androgen receptors, testosterone’s effect on thrombopoiesis in humans has never been studied.We report a case of 53-years-old woman presented with androgenic alopecia, hirsutism, facial redness and hoarse voice. She was a non-smoker and had a history of well-controlled diabetes mellitus...

We report a 17-year-old male who presented with symptoms of absent secondary sexual characteristics, decreased appetite and infrequent non-specific abdominal pain. He had no complaints of headache, altered sense of smell or colour blindness. His other siblings had normal growth.On examination, he had normal male body habitus, height (157 cm), no gynaecomastia, axillary and beard hair (tanner stage 1) pubic hair (tanner stage 2), testes (12 ml bilaterally...

A case of ectopic ACTH with severe opportunistic infectionECI Hatfield, S Pal, K Meeran, G Williams, JF Todd.Endocrine Unit, Imperial College, Hammersmith Hospital, London, UKA twenty six year old female presented with symptoms and signs suggestive of Cushing's Syndrome. Initial investigations showed hypokalaemia (potassium 2.3nmol/L), elevated urinary free cortisols, (3400, 18,000, 31,000 nmol/24 hour (NR <270)), diabetes (fasting glucose =9 mmol/L), loss of di...

Introduction: Mechanism underlying glucose-mediated development and progression of diabetic complication are incompletely understood. Atrial natriuretic peptide (ANP) is a hormone released by atrial myocytes in response to acute and chronic extracellular volume expansion. Moderate hyperglycaemia (>400 mg/dl) in diabetic rats is associated with an elevation in circulating ANP levels and in GFR (glomerular filtration rate), (1) and play a role in the development of microalbu...

Primary HPT shows a great variability in its clinical course and severity, which might be related to polymorphic variants of the CASR gene. The aim of the study was to evaluate the frequency of two known CASR single nucleotide polymorphisms (SNPs), i.e. G/T at codon 986 and G/A at codon 990, in a homogenous North-Italian cohort of PHPT patients compared with a sex and age matched healthy population and the possible correlation of these CASR gene variants with the clinical and ...

Objective: Cushing’s disease (CD) is difficult to diagnose because of its rarity and because its most common symptoms can overlap with those of other more common conditions. Remission rates in the postoperative vary between 55–85%. Overall, the mean time to diagnosis was 38 months. The objective of this study was to describe whether there is any pre-surgical clinical data that predicts CD remission after TSS.Patients and Methods: Retrospectiv...

Introduction: Thyroid disorders affect metabolism and body composition; however, literature data have been conflicting on whether this is also the case for thyroid hormone levels within the euthyroid range. Therefore, we have investigated the relationship between indices of thyroid status and both body composition and metabolic parameters in a population of healthy euthyroid men.Methods: Healthy male siblings (n=941, 25–45 years, median BMI 2...